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ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries

Research Area: Biomedicinski inzenjering Year: 2011
Type of Publication: Article
  • Filipović, Nenad
  • Rosić, Mirko
  • Tanasković, Irena
  • Milošević, Žarko
  • Nikolić, Dalibor
  • Zdravković, Nebojša
  • Fotiadis, D.
  • Parodi, O.
  • Peulić, Aleksandar
Journal: IEEE Trans Inf Technol Biomed
Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall. In this study a continuum based approach for plaque formation and development in three-dimension is presented. The blood flow is simulated by the three-dimensional Navier-Stokes equations, together with the continuity equation while LDL transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also three-dimensional model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.