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Computer Simulation of Plaque formation and Development

Research Area: Uncategorized Year: 2011
Type of Publication: Article Keywords: Atherosclerosis, Computer simulation, Plaque formation
  • Filipovic, Nenad
  • Meunier, N.
  • Kojic, Milos
  • Isailovic, Velibor
  • Radovic, Milos
  • Milosevic, Zarko
  • Nikolic, Dalibor
  • Milasinovic, Danko
  • Exarchos, T.
  • Parodi, O.
  • Fotiadis, D.
Journal: IPSI BgD journals Volume: 7
Number: 2
Atherosclerosis develops from oxidized low-density lipoprotein molecules (LDL). When oxidized LDL evolves in plaque formations within an artery wall, a series of reactions occur to repair the damage to the artery wall caused by oxidized LDL. The body's immune system responds to the damage to the artery wall caused by oxidized LDL by sending specialized white blood cellsmacrophages (Mphs) to absorb the oxidized-LDL forming specialized foam cells. Macrophages accumulate inside arterial intima. Also Smooth Muscle Cells (SMC) accumulate in the atherosclerotic arterial intima, where they proliferate and secrete extracellular matrix to form a fibrous cap. In this study, we simulate a process of atherosclerosis formation and development and compare it with literature data. The 3D blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the blood flow and is modeled by the convection-diffusion equation. LDL transport in lumen of the vessel is described by Kedem-Katchalsky equations. The inflammatory process is solved using three additional reactiondiffusion partial differential equations. The understanding and the prediction of the evolution of atherosclerotic plaques either into vulnerable plaques or into stable plaques are major tasks for the medical community